Vosch Group - Nanospectroscopy

Projects

In my group, you can work with small silver clusters stabilized with DNA or peptides (1-20 atoms) to understand and characterize the fundamental spectroscopic properties of these new fluorescent markers.

Currently, we investigate how to opti-mize these markers for use in high-resolution flu-orescence microscopy (STORM/STED).

Additionally, there are several possible projects in micro-Raman spectroscopy and SERS on a variety of materials such as carbon nanotubes, nanowires, nanorods etc.

Collaborations

The projects are in collaboration with Jesper Nygård, Thomas Sand Jespersen and Kasper Nørgaard.

Here you can find compositional and photophysical information on HPLC purified DNA-stabilized silver nanoclusters.

Click on the DNA sequence to see the specific information.

We now also have a dedicated external database: https://countingphotons.github.io/DNA_AgNC_database/index.html 

If you want to learn more about this topic, check out the review by the Copp and Vosch research groups: https://pubs.rsc.org/en/content/articlepdf/2021/NA/D0NA01005G 

Acknowledgements

• Villum Fonden VKR023115
• Independent Research Fund Denmark 0136-00024B
• Novo Nordisk Fonden NNF22OC0073734

Notes

7/4/2021: All DNA-AgNCs were HPLC-purified with a column of 250 mm length. In some papers there is a typo in the description stating the length was 50 mm.

In collaboration with the group of Prof. Jurgen Hauer (Technical University Munich), Prof. Giulio Cerullo and Prof. Dario Polli (Polytechnic University of Milan), we developed a single molecule fluorescence setup that allows recording 2D excitation and emission maps of single molecules.

In an alternative configuration it allows measuring 2D excitation wavelength versus decay time maps. Key components on the excitation part are a continuum laser source and a newly developed common-path interferometer.

A movie explaining the concept of the common-path interferometer and the demonstration of it at the single molecule level can be found here

Here you can find information on the efforts in imaging lanthanide emission. Most of the work has been done in collaboration with:

• Thomas Just Sørensen (University of Copenhagen)
• Tero Soukka (University of Helsinki)

Selected research publications

• A Mixed-Valent and High-Spin Vanadium Phosphide
  Chandran, A., Sandoval-Pauker, C., Pinter, B., Vosch, T., Wilhelm, F., Rogalev, A., Pedersen, K. S. & Reinholdt, A., 2026, In: Journal of the American Chemical Society. 148, 9, p. 9629-9639 11 p.
• Bridging the gap: thymine segments to create single-stranded versions of DNA₂-[Ag₁₆Cl₂]8₊
  Rück, V., Kanazawa, H., Huang, Z., Mollerup, C. B., Lo Leggio, L., Kondo, J. & Vosch, T., 2026, In: Inorganic Chemistry Frontiers. 13, 7, p. 3149-3153
• Insights into the crystal packing interactions of a 960-nm-emissive DNA-stabilized silver nanocluster
  Romolini, G., Kanazawa, H., Lind, S. W., Cerretani, C., Mollerup, C. B., Liccardo, L., Huang, Z., Lo Leggio, L., Rück, V., Kondo, J. & Vosch, T., 2026, In: Chemical Communications. 62, p. 3283-3286
• Real-Time In Vivo Detection of Nanocarrier Number and Velocity in the Cerebrovasculature Using Hot Band Absorption
  Wang, X., Liisberg, M. B., Rück, V., Pande, S., Nolt, G. L., Li, L., Yin, Q., Harvey, B. T., Nagel, J., Fu, X., Johnson, L. A., Vosch, T. & Richards, C. I., 2026, In: Small. 22, 17, 15 p.
• Two of a Kind: Composition and Photophysics of Two Silver Nanoclusters Stabilized by the Same DNA Sequence
  Liccardo, L., Kanazawa, H., Romolini, G., Cerretani, C., Lind, S. W., Polido, B., Mollerup, C. B., Ruck, V., Huang, Z., Lo Leggio, L., Kondo, J. & Vosch, T., 2026, In: Journal of the American Chemical Society. 148, 25, p. 25989–25995 7 p.

See the full list of publications