Thulstrup Group - Bioinorganic Chemistry and Spectroscopy

Understanding biomolecular structure and function through spectroscopic investigations

Research focus

Spectroscopic investigations of molecular structure and function

In my lab, we characterize molecular structure, function and dynamics through optical spectroscopic methods.

We often focus on biological systems, specifically within bioinorganic chemistry at the interface of biological and inorganic chemistry. 

Group leader

Research aim

The aim of the research is typically to understand a fundamental property of a given molecular system, be it an enzymatic process, a self-assembly reaction, or a compound of purely spectroscopic interest. The work is experimental but may be aided by application of theoretical modelling. Typically, we rely on absorbance, fluorescence, linear and circular dichroism spectroscopy to name the most prevalent methods used.

The aim of our spectroscopic research is typically to understand a fundamental property of a given molecular system: How a protein folds, takes part in an enzymatic process, or undergoes a self-assembly reaction. Typically, we rely on absorbance, fluorescence, linear and circular dichroism spectroscopy, and mass spectrometry to name the most prevalent methods used. Our experimental work benefits from being aided by the application of theoretical modelling.

We synthesize new compounds and conjugates aimed at obtaining new functional properties. We often focus on biological systems, specifically within bioinorganic chemistry at the interface of biological and inorganic chemistry. Current research topics under investigation include synthesis of novel siderophore-antibiotic conjugates and development of well-defined fluorescent silver nanocluster systems.

Peter Thulstrup is often engaged in collaborative research and he is interested in extending his research network.

Projects and teaching

As a supervisor, I emphasize that my students should have a large influence on the chosen subject and methodology. I am always open to new ideas and suggestions. Specific projects that are ongoing right now include: 

  1. The role of metal ions in protein and peptide folding and misfolding
  2. Structural characterization of fluorescent Ag-nanoclusters in DNA/RNA
  3. Natural compounds affecting structure and dynamics of nucleic acids
  4. Orientation of molecules in polymers, liquid crystals, and membranes
  5. Design of ligands for metal ion binding and selective detection.

Contact

Peter W. Thulstrup
Associate Professor
  • Job responsibility
    Group leader