Scientists locate disease switches
17 July 2009
A team of scientists from the University of Copenhagen
and the Max Planck Institute in Germany, using
groundbreaking technology, has identified no less than 3,600
molecular switches in the human body.
These switches, which regulate protein functions, may
prove to be a crucial factor in human ageing and the onset
and treatment of diseases such as cancer, Alzheimer's
disease and Parkinson's disease. The results of the team’s
work have been published in the current edition of the
New perspectives in the treatment of disease
The team, led by Professor Matthias Mann of Novo Nordisk
Center for Protein Research at the University of Copenhagen
and the Max Planck Institute for Biochemistry in Germany,
have detected 3,600 acetylation switches in 1,750 different
"This is more than just a technological achievement, it
has also expanded the number of known acetylation switches
by a factor of six, and it gives us for the first time a
comprehensive insight into this type of protein modification,"
says Professor Mann.
A given protein can perform more than one task, and how
it behaves is regulated by adding a small molecule that acts
as a 'switch' which can turn on the different tasks.
Acetylation is essential for cells' ability to function
normally. Defective protein regulation plays a role in
ageing and the development of diseases such as cancer,
Parkinson's and Alzheimer's.
"With the new mapping, we can now begin to study and
describe how acetylation switches respond to medications
that could repair the defects on them. It can have a major
impact on medical care," says Professor Mann, adding that
medications to repair the damaged protein regulation are
already showing promising in the treatment of cancer.
The team also discovered that acetylation modification
occurs primarily on proteins that work together, and that
these switches have much greater consequences for the
organism's function than previously thought. In one example,
the function of Cdc28, an important growth protein in yeast,
can be disrupted by the addition of an acetylation button,
ultimately affecting the organism's ability to survive.
The results of the team's research were published in the
17 July 2009 edition of Science.